Faculty

Expand all Collapse all

• Prof. Thumbi Ndung'u

  Professor Thumbi Ndung'u Scientific Director Ndungu@ukzn.ac.za

  Professor Thumbi Ndung’u, B.V.M., PhD is the Scientific Director of the HIV Pathogenesis Programme (HPP) at the Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal. He holds the South African Research Chair in Systems Biology of HIV/AIDS and the Victor Daitz Chair in HIV/TB Research at the University of KwaZulu-Natal. Professor Ndung’u is an Investigator and Max Planck Institute for Infection Biology Research Group Leader at the KwaZulu-Natal Natal Research Institute for Tuberculosis and HIV (K-RITH). In January 2012, he was one of the recipients of the inaugural Howard Hughes Medical Institute International Early Career Scientist award. He is an Associate Member of the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University and a Visiting Scientist at Massachusetts General Hospital.

   

  Professor Ndung’u graduated with a degree in Veterinary Medicine from the University of Nairobi, Kenya, and obtained a PhD in Biological Sciences in Public Health from Harvard University. He then undertook postdoctoral studies in Virology at Harvard Medical School. He is a past recipient of the Edgar Haber award (Harvard University), the Vice-Chancellor’s research award (University of KwaZulu-Natal) and the Friedland Senior Health Researcher Prize (South Africa). In 2012, he was a finalist for National Science and Technology Forum/BHP Billiton Awards for outstanding contribution to Science, Engineering, Technology and Innovation (SETI) in the category of research capacity development over the last 5 to 10 years. From 2008 to 2011, he co-chaired the Young and Early Career Investigators Committee (YECIC) of the Global HIV Vaccine Enterprise and played a key role in the formulation of the Enterprise’s 2010 Scientific Strategic Plan. He is a member of the scientific advisory board of the southern African Consortium for Research Excellence (SACORE), a research consortium of five southern African Universities and their counterparts from the United Kingdom. He is on the external advisory committee of the Universidade Eduardo Mondlane-University of California, San Diego Medical Education Partnership.

   

  Professor Ndung’u’s research interests are host-virus interactions, antiviral immune responses and biomedical interventions applicable to resource-limited settings. Professor Ndung'u has published in peer-reviewed journals in the fields of virology, immunology and biomedical research policy. He has successfully supervised more than 20 postgraduate students and postdoctoral researchers. He has received grant funding from diverse sources including the National Research Foundation of South Africa, the International AIDS Vaccine Initiative (IAVI), the National Institutes of Health (United States), the European Union, the Canadian Global Health Research Initiative, the Max Planck Society and the Howard Hughes Medical Institute (United States). He leads a multidisciplinary team of researchers working in the fields of HIV and TB pathogenesis and vaccine development. He has special interest in capacity building for biomedical research in Africa.
  

  
  

  ResearchGate Profile

• Prof. Bruce Walker

  Professor Bruce Walker Harvard University

  Professor Bruce D Walker is an Adjunct Professor at Harvard Medical School and the Director of the Ragon Institute of MGH, MIT and Harvard. He is the Director of the Harvard University Center for AIDS Research (CFAR). He holds a joint appointment as Professor of Medicine at the University of KwaZulu Natal. Professor Walker’s clinical specialty is infectious disease, focusing on HIV/AIDS and he has led the HIV research field from the mid-1980’s identifying cytotoxic T lymphocytes as key participants in effective control of HIV infection. This work, and other work he has done, laid the foundation for detailed understanding of immune responses to HIV, but had focused on the strains of a viral clade found in the US and Europe and defined responses in the context of Caucasian HLA types. A different viral clade is most prevalent in South Africa and is responsible for the majority of new infections world-wide.  Thus, Walker initiated a pilot research program in 1998 in Durban, South Africa on HIV pathogenesis, with Professor Hoosen Coovadia.  Since then, Walker and his collaborators have received additional financial support and expanded this work; in 2003 Walker helped to secure funding to create the Doris Duke Medical Research Institute (DDMRI) in Durban aimed at creating a synergistic research environment using extensive collaborations among the major sites of HIV research and treatment within South Africa.

   

  ResearchGate Profile

   

• Prof. Philip Goulder

  Professor Philip Goulder Oxford University

  Professor Philip Goulder is Professor of Immunology at the University of Oxford in the United Kingdom and has a joint appointment as Professor of Pediatrics at the University of KwaZulu Natal. He co-initiated the HIV Pathogenesis Programme with Professors Walker and Coovadia in Durban in 1998. Professor Goulder is a world recognized leader in the role of genetic variation, particularly human leukocyte antigens in the control of HIV-1. Professor Goulder has led seminal work on HLA-mediated immune control of HIV in South Africa. This work has been published in leading international journals such as Nature, Nature Medicine, Journal of Experimental Medicine and others. Professor Goulder has held active grants on HIV research in Durban since 1998. These funds have come from diverse donors such as the United States’ National Institutes of Health, Microsoft and the Wellcome Trust among others. He has helped to supervise students and other researchers in the HIV Pathogenesis Programme including masters and PhD students. His work has been undertaken in both pediatric and adult cohorts and has contributed significantly to the understanding of immune control of HIV-1 and to the development of new policy guidelines for the management of pediatric HIV infection in South Africa.

  ResearchGate Profile

   

• Prof. Marcus Altfeld

   

  Professor Marcus Altfeld Heinrich-Pette-Institut

  Professor Marcus Altfeld is a Professor in Medicine and serves as the Director of the Department of Virus Immunology at the Heinrich-Pette-Institut, a Leibniz Institute for Experimental Virology, and as Chair of the Institute for Immunology at the University Medical Center Hamburg-Eppendorf in Hamburg. He holds an appointment as Honorary Professor of Microbiology at the University of KwaZulu-Natal. Prof. Altfeld’s research is directed towards the characterization of innate immunity in viral infections, with focus on HIV-1 and Hepatitis Virus infections. The aim of this research is to understand the correlates of protective immunity in viral infections, and in particular, how the initial activation of the innate immune system by pathogens shapes the quality of the adaptive immune response. The long term goal of this research is to harness innate immunity for the development of protective vaccines. Prof. Altfeld has a long-standing collaboration with the HIV Pathogenesis Programme, DDMRI/UKZN, studying innate immunity in HIV-1 and HIV-1/Tb co-infection.

• Dr. Christina Tshabalala

  Dr. Christina Tshabalala Senior Lecturer and Researcher Thobakgalec@ukzn.ac.za

  Dr. Christina Tshabalala is a Senior Lecturer and Researcher at the HIV Pathogenesis Programme (HPP) at University of KwaZulu-Natal. She graduated with a PHD from the University of KwaZulu-Natal, followed by a Postdoctoral Fellowship with the HPP and the Ragon Institute of MGH, MIT and Harvard. For the past few years her research focused on understanding cellular and viral factors that influenced disease progression in HIV-infected infants. Currently, her research focuses on innate immune responses to HIV, particularly mechanisms of NK cell dysfunction during acute and chronic infection and their impact on the ability of NK cells to control HIV infection. As a product of the training through the HPP programme, Dr. Tshabalala has a keen interest in the development of young scientists. She has collaboration with researchers at Harvard and Oxford Universities and is an author and co-author of several publications. It is anticipated that her work will shed knowledge on the identification of molecular mechanisms that underlie NK cell-mediated protection in HIV infection, manipulation of which could be important for therapeutic interventions.

  ResearchGate Profile
  

• Dr. Jaclyn Mann

  Dr. Jaclyn Mann Senior Lecturer and Researcher Mannj@ukzn.ac.za

  Jaclyn Mann, PhD (Virology), is employed as a lecturer and researcher in the HIV Pathogenesis Programme (HPP), School of Laboratory Medicine and Medical Sciences, at the Nelson R. Mandela School of Medicine, UKZN. Her research is focused on investigating the effect of immune-driven mutations on the function of HIV-1 proteins and the replication capacity of the virus, with the broad aim of identifying which immune responses may be effective in controlling HIV-1 infection. 

  ResearchGate Profile