Dr Zaza Ndlovu


Dr. Zaza Ndhlovu


 +27 (031 260 4810




Nelson Mandela School of Medicine

Research Interests

HIV Vaccine Immunology


Honorary Lecturer


Dr. Zaza Ndhlovu’s studies seek to understand the mechanism by which rare people who are able to control viral replication in the absence of therapy (elite controllers) achieve long-term asymp¬tomatic infection. Dr. Ndhlovu and his colleagues have made significant discoveries about key features of HIV-specific killer T lymphocyte subsets that are able to inhibit viral replication and drive immune escape in elite controllers; characterizing these T cell subsets is crucial to the development of T cell based vaccines for HIV and other infectious agents. In addition to contributing vitally to vaccine science, Dr Ndhlovu also conducts scientific reading and grant writing workshops for African scientists at various African Universities.
Dr. Ndhlovu is an Instructor of Medicine at Harvard Medical School, Assistant in Immunology at Massachusetts General Hospital and a Senior Lecturer at the University of KwaZulu Natal HIV Pathogenesis Programme. He received his Ph.D. in Molecular Microbiology and Immunology from Johns Hopkins University and received his pos-doctoral training at the Ragon Institute in the laboratory of Dr Bruce Walker. He has recently set up his lab at the University of KwaZulu Natal’s Nelson Mandela School of Medicine, HIV Pathogenesis Programme.
Currently, Dr Ndhlovu leads the collection and processing of longitudinal samples from individuals with acute HIV-1 infection in Durban South Africa. He uses these samples to investigate the dynamics of cellular immune responses in acute HIV infection and to define the ontogeny of HIV-specific CD4+ T cell responses and their relationship to the establishment of bNAbs. 

Lab Info: Principle Investigator: Zaza Ndhlovu Ph.D.

ResearchGate Profile

List of Publications 

1. Kløverpris HN, Kazer SW, Mjösberg J, Mabuka JM, Wellmann A, Zaza M Ndhlovu,.Leslie A. Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression Immunity. February 2016 Immunity. 2016 Feb pg1074-7613 

2. Zaza M Ndhlovu,. Walker BD. Magnitude and Kinetics of CD8+T cell Activation during Hyperacute HIV infection Impact viral load setpoint, Immunity 2015 September 5;43(3):591-604

3. Zaza M. Ndhlovu,. Walker BD: The breadth of expandableCD8+ T cell immune responses and association with progressive control of viremia in early HIV-1 infection despite limited evidence of immune pressure. J Virol. 2015 November 89(21):10735-47

4. Radebe M, Gounder K, Mokgoro M, Zaza M Ndhlovu,.Ndung'u T: Dynamics of memory CD8+ T cells Inversely correlates with residual viral loads in HIV Elite controllers AIDS. 2015 January 2;29(1):23-33

5. Huabiao Chen, Zaza M Ndhlovu,. Bruce D Walk: T cell receptor usage modulates the antiviral efficacy of protective HLA class I alleles in HIV-1 infection; (Shared-first author, Nature Immunology April 2012) 2012 Jun 10;13(7)

6. Youngblood B, Noto A, Porichis F, Akondy RS, Zaza M Ndhlovu,. Kaufmann DE. Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-pecific CD8 T cells; Cutting edge, J Immunol. 2013 Ju,l J Immunol. 2013 Jul 15;191 (2):540-4

7. Zaza M Ndhlovu,.Kaufmann DE: A high-dimensional immune monitoring model of HIV-1-specific CD8 T cell responses accurately identifies subjects achieving spontaneous viral control. Blood Jan 2013. 2013 Jan 31;121(5):801-11

8. Zaza M. Ndhlovu,.Walker BD, Pereyra F: Elite controllers with low to absent effector CD8+ T cell responses maintain   highly functional, broadly directed central memory responses: Journal of virology, April 2012 Jun;86(12):6959-69

9. Zaza M Ndhlovu,.Walker BD: Mosaic HIV-1 Gag Antigens Process and Present HIV CTL Epitopes to Human T cells: Journal of Immunology. June, 2011 15;186(12):6914-24.

10. Zaza M Ndhlovu,. Diane E. Griffin: Dynamic regulation of functionally distinct virus-specific T cells: Proceedings of National Academy of Sciences of the United States of America (PNAS). February, 2010 23;107(8):3669-74.

11. Zaza M Ndhlovu,. Mathias Oelke: Development of an artificial antigen-presenting cell (aAPC)-based assay for the detection of low frequency virus-specific CD8+T cells in whole blood with application to measles virus: Clinical and Vaccine Immunology Journal, 2009. 6(7):1066-73.

12. William J. Moss, Susana Scott, Nanthalile Mugala, Zaza Ndhlovu,. Felicity T. Cutts: Immunogenicity of standard-titre measles vaccine in HIV-1 infected and uninfected Zambian children: J Infect Dis 2007; 196:347-355.

13. Nitya Nair, William J. Moss, Susana Scott, Nanthalile Mugala, Zaza M. Ndhlovu,.Diane E. Griffin: HIV-1 infection of Zambian children impairs development and avidity maturation of measles virus-specific IgG following vaccination and infection: J Infect Dis 2009:200. 200(7):1031-8. 

14. William J. Moss, Susana Scott, PhD Zaza Ndhlovu Diane E. Griffin: Suppression of human immunodeficiency virus type 1 viral load during acute measles: Pediatr Infect Dis J. 2009 Dec 3l. Jan;28(1):63-5. 

15. Catherine G. Sutcliffe, Susana Scott, Nanthalile Mugala, Zaza Ndhlovu,.William J. Moss: Survival from 9 Months of Age among HIV-Infected and Uninfected Zambian Children Prior to the availability of Antiretroviral Therapy. Clin Infect Dis. 2008 Sep 15; 47(6):837-44. 

16. Martin O. Ota, Zaza Ndhlovu,.Diane E. Griffin1: Hemagglutinin protein is a primary target of the measles virus-specific HLA-A2-restricted CD8+ T cell response during measles and after vaccination:  J Infect Dis 2007; 195:1799-1807.

17. Zaza Ndhlovu,.William J. Moss: CD4+ and CD8+ T-lymphocyte subsets in Zambian children: J Trop Pediatr 2004 ; 50:94-7

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